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  1. Our research
  2. Completed projects

Completed projects

Below you will find information about research projects we have previously funded. Learn more about our current projects or visit the EB Research Network for more information on EB research.

Projects funded by Cure EB (previously Sohana Research Fund):

  • EBSTEM (2015) – A Phase I/II Clinical Trial of mesenchymal stromal cells (MSC) in RDEB
  • Tolar 2 (2015) – To develop TALEN gene-correction technology re individualised stem-cell therapy options for children with RDEB
  • Qasim 2 (2014; administered by DEBRA) - funding towards the purchase of high speed and ultracentrifuge equipment required for the translational research in the pre-clinical development of gene therapies for EB.
Gene therapy for EBS and RDEB

Gene therapy for EBS and RDEB

Dr Peter van den Akker, Dundee, UK Read more

Published: 30th July, 2020

Updated: 7th June, 2022

Author:

Sonnenberg (2013)

Studying Kindler Syndrome in a zebrafish model system Read more

Published: 1st November, 2021

Updated: 1st December, 2021

Author: Kat Heppinstall

South (2013)

Preclinical assessment of PLK 1 inhibitors for the treatment of recessive dystrophic epidermolysis bullosa associated with squamous cell carcinoma Read more

Published: 1st November, 2021

Updated: 1st December, 2021

Author: Kat Heppinstall

McLean/Heagerty 1 (2014)

To be in a position to move to clinical trials of siRNA on EB Simplex Read more

Published: 1st November, 2021

Updated: 1st December, 2021

Author: Kat Heppinstall

Liossi (2014)

Quality of life in young people with Epidermolysis Bullosa Read more

Published: 1st November, 2021

Updated: 1st December, 2021

Author: Kat Heppinstall

McGrath (2014)

Determining the molecular basis of currently uncharacterised forms of Epidermolysis Bullosa Read more

Published: 1st November, 2021

Updated: 1st December, 2021

Author: Kat Heppinstall

O'Toole (2015)

Dissecting the role of basement membrane components in a xenograft model of cutaneous SCC Read more

Published: 1st November, 2021

Updated: 1st December, 2021

Author: Kat Heppinstall

Hubbard 1 (2017)

Longitudinal retrospective study on bone health in adults with RDEB Read more

Published: 1st November, 2021

Updated: 1st December, 2021

Author: Kat Heppinstall

Roopenian 2 (2017)

To identify modifier genes in Junctional EB that affect the severity of symptoms experienced by different patients with the same primary gene defect Read more

Published: 1st November, 2021

Updated: 1st December, 2021

Author: Kat Heppinstall

Tolar 3 (2017)

Limbal stem-cell therapy for RDEB Read more

Published: 1st November, 2021

Updated: 1st December, 2021

Author: Kat Heppinstall

Gaggioli 2 (2017)

To validate findings that will develop a drug to counteract scarring and Squamous Cell Carcinoma in patients with Recessive Dystrophic EB Read more

Published: 1st November, 2021

Updated: 1st December, 2021

Author: Kat Heppinstall

Bauer 5 (2017)

To develop therapies which combine ex vivo gene therapy with stem cell transplantation for Junctional EB. Read more

Published: 1st November, 2021

Updated: 1st December, 2021

Author: Kat Heppinstall

Uitto 1 (2017)

Novel approaches for read-through of nonsense mutations in COL7A1 Read more

Published: 1st November, 2021

Updated: 1st December, 2021

Author: Kat Heppinstall

Brunton 1 (2018)

Defining the role of kindlin-1 in the regulation of microtubule stability and mitosis Read more

Published: 1st November, 2021

Updated: 1st December, 2021

Author: Kat Heppinstall

ADSTEM (2018)

Cell therapy research sees quality of life improvement in a clinical trial for adults (ADSTEM) with Recessive Dystrophic Epidermolysis Bullosa *Project funded by Cure EB Read more

Published: 1st November, 2021

Updated: 1st December, 2021

Author: Kat Heppinstall

LENTICOL F (2019)

Can gene-modified skin cells provide a useful treatment for RDEB? *Project funded by Cure EB Read more

Published: 1st November, 2021

Updated: 1st December, 2021

Author: Kat Heppinstall

Inman-South 1 (2019)

TGF-β signalling in RDEB Squamous Cell Carcinoma Read more

Published: 1st November, 2021

Updated: 1st December, 2021

Author: Kat Heppinstall

Hickerson 2 (2019)

Investigating the use of Ultrasound as a Delivery Mechanism for an Epidermolysis Bullosa Simplex Therapy Read more

Published: 1st November, 2021

Updated: 1st December, 2021

Author: Kat Heppinstall

Hickerson 1 (2019)

Development of a Skin Fragility Assessment Tool Read more

Published: 1st November, 2021

Updated: 1st December, 2021

Author: Kat Heppinstall

McLean 12 (2019)

EBS Genotyping Database Read more

Published: 1st November, 2021

Updated: 1st December, 2021

Author: Kat Heppinstall

Eming 1

Understanding the complications of wound healing in patients with Recessive Dystrophic Epidermolysis Bullosa Read more

Published: 1st November, 2021

Updated: 13th May, 2022

Author: Kat Heppinstall

Treating DEB itch with stem cells

Treating DEB itch with stem cells

Prof John McGrath, London, UK Read more

Published: 1st November, 2021

Updated: 7th June, 2022

Author: Kat Heppinstall

South 3

"First in EB" Phase II trial of Rigosertib for RDEB SCC Read more

Published: 1st November, 2021

Updated: 13th May, 2022

Author: Kat Heppinstall

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Showing 10 of 23

Latest

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    Filsuvez® gel approved for use in the EU

    The UK is a step closer to having the first approved treatment for EB patients.

  • Mark Algar and Paul Buckworth complete 113km Ultramarathon to help #FightEB!

    Mark Algar and Paul Buckworth complete 113km Ultramarathon to help #FightEB!

    On the 18th June 2022, Mark Algar & Paul Buckworth took on an 113km Ultramarathon to help #FightEB.

  • Leave a legacy

    Leave a legacy

    Leaving a gift in your will is a simple but vital way to help make sure DEBRA is there to provide care and support to people living with EB and fund life changing research.

  • DEBRA Memory Makers campaign raises £55,119!

    DEBRA Memory Makers campaign raises £55,119!

    Our #DEBRAMemoryMakers campaign has raised an incredible £55,119.30 towards our DEBRA holiday homes!

Most read

  • Furniture collection

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  • Contact Us

  • What is EB?

    What is EB?

    Epidermolysis Bullosa (EB) is a painful genetic skin blistering condition with no cure. Find out about different types of EB, causes, symptoms and treatments.

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    Donate your quality pre-loved items, including clothes, furniture and homeware to keep them from landfill and help us to raise vital funds through our stores. Find out more about how to donate items today.

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    Work with us

    DEBRA can only continue its vital work with the support and encouragement of the local community and with the hard work of its employees and volunteers.

  • Who we are

    Who we are

    DEBRA is the national charity that funds research and healthcare to support individuals and families affected by Epidermolysis Bullosa (EB)

  • Dystrophic EB (DEB)

    Dystrophic EB (DEB)

    Can be mild or severe (dominant or recessive). The defective gene and fragility occurs below the basement membrane within the superficial dermis.

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