01. Types of EB Epidermolysis bullosa is a spectrum of diseases with symptoms that can be different from one person to the next. Different types of EB can be caused by changes in the genes for skin proteins like keratin and collagen. Within each type, symptoms can be more or less extreme and there are quite a few named sub-types of EB where a slightly different set of symptoms have been described by a researcher. In 2020 a DEBRA-funded expert consensus report was published that reclassified all genetic EB into one of four types: EB simplex EBS 70% of EB cases Keratin (Keratin-5 and Keratin-14) Epidermolysis bullosa simplex | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program (nih.gov) Dystrophic EB DEB 25% of EB cases Collagen (Collagen -7) Dystrophic epidermolysis bullosa | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program (nih.gov) Junctional EB JEB 5% of EB cases Laminin or collagen-17 Junctional epidermolysis bullosa | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program (nih.gov) Kindler EB KEB Less than 1% of EB cases Kindlin-1 Kindler syndrome | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program (nih.gov) This animation explains a bit about epidermolysis bullosa (EB) at the molecular level: The Genetic Alliance UK website provides information about genetic conditions in general. Manage Cookie Preferences