EB Simplex

The most common form of Epidermolysis Bullosa, EB Simplex (EBS) is characterised by a lack of adhesion of the skin directly above the basement membrane (the basal layer).

Approximately 70% of people with EB have EBS. Most forms of EBS are inherited as dominant traits meaning the parents also demonstrate visible clinical signs of the condition. EBS typically manifests itself as blistering confined to the hands and feet. In another form of EBS, skin blisters can occur all over the body.

Blistering generally appears during the neonatal period but it can also manifest itself in later childhood (or even in adult life). Painful skin blisters are accentuated by rubbing, especially on the feet where footwear causes increased irritation. People living with EBS have to cope with a range of complications – rubbing is worse in warm weather and infections are common.