You are here: About EB > Types of EB > Dystrophic EB
Dystrophic EB

Dystrophic EB

Dystrophic EB (DEB) is a genetic skin condition characterised by a lack of adhesion of the skin under the basement membrane.

Approximately 20% of people with EB have DEB. DEB may be inherited as a dominant or recessive trait. DEB derives its name from the tendency of the blisters to heal with scarring, leading to contraction of the joints, fusion of the fingers and toes, contraction of the mouth membranes and narrowing of the oesophagus.

The severity of DEB varies widely. Often the dominant inherited type of DEB is the least severe type and the patient can lead an almost normal life. However, the severity of the condition does increase with age due to scarring, fusion of the fingers and wastage of skin tissue.

People living with Recessive DEB (RDEB) have a high chance of developing a squamous cell carcinoma (a form of aggressive skin cancer) before the age of 35.

Josh's story

Josh's story

DEBRA has been able to support the family by helping towards the provision of an electric wheelchair to give Josh the independence he craves.

READ HIS STORY