Genes are generally made up of exon sequences (where the As, Ts, Cs and Gs code for protein as described above) and intron sequences (where it doesn’t spell out a protein - don’t ask what it does do – it gets complicated!). The collagen gene involved with DEB (COL7A1) has over a hundred exons with introns in between. For the protein to be made, the message jumps from exon to exon and ignores the introns. If one of the exons contains a change that causes the whole protein to be broken, a type of therapy called ‘exon skipping’ can be used to make a protein that leaves out some of the exons, so is a bit shorter, but still works. This therapy has the potential to help people with EB and already been used in a different genetic condition called Duchenne Muscular Dystrophy.